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The primary endogenous substrates for CYP4F11 are long-chain 3-hydroxydicarboxylic acids (3-OHDCA) and the enzyme is also very active at hydroxylating various xenobiotics
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To further confirm the cells were dying in a lytic manner, we also imaged THP-1 cell lines induced to express X(PC) with 0.5 g ml 1 doxycycline for 12 h every 10 min
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