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Treatment with CDDO-Me increased NRF2 expression but not to the level observed in the liver of Gclc L-KO mice, as we could only detect substantial NRF2 expression after enriching the whole protein lysate for a nuclear fraction (Fig
37, 42, 43, 48, 49 However, although GSH attenuated fragmentation resulting from metabolite exposure, GSH did not attenuate metabolite-induced mitochondrial fragmentation in pink-1 (RNAi) backgrounds
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