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The parent protein was identified during investigations of compounds in human gastric juice that conferred protection against ulceration, and the active 15-residue fragment retained the full activity of the larger protein in subsequent characterisation studies
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Clinical Evidence Human Trials: A randomized, placebo-controlled study in obese adults demonstrated that AOD-9604 significantly reduced abdominal and total body fat over several weeks of treatment, without serious side effects Animal Studies: Preclinical studies in mice and rats showed that AOD-9604: Stimulated lipolysis Inhibited lipogenesis (formation of new fat) Prevented weight gain despite high-fat diets This dual actionenhancing fat breakdown and inhibiting fat formationpositions AOD-9604 as a potent tool for combating obesity
/Paris/, 1997, 91, 173178)
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