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It was designed by Al-Obeidi, Castrucci, Hadley and Hruby and reported in the Journal of Medicinal Chemistry in 1989, using quenched molecular dynamics to select which conformation of the alpha-MSH 4-10 message sequence to constrain
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10.1073/pnas.0400348101 Proc
While it has shown promising results, it is important to consider the potential side effects, cost, and the need for further research to determine its long-term safety and efficacy
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