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In G6PD-deficient red blood cells, the NADPH needed to reduce MB (and methemoglobin) is insufficient, causing MB to instead induce oxidative stress on the cells

Common symptoms of iron deficiency include: Fatigue and weakness persistent tiredness that does not improve with rest Pallor pale skin, nail beds, and mucous membranes (inside lower eyelids) Shortness of breath particularly on exertion or during activities previously well-tolerated Dizziness or light-headedness especially when standing quickly Cold hands and feet due to reduced oxygen delivery to extremities Headaches often frontal and persistent Rapid or irregular heartbeat (palpitations) Brittle nails or koilonychia (spoon-shaped nails) in more advanced cases Sore or swollen tongue (glossitis) Unusual cravings for non-food items such as ice, paper, or starch (pica) Restless legs syndrome uncomfortable sensations in legs with urge to move them Difficulty concentrating or impaired cognitive function It is important to note that these symptoms may develop gradually and can be subtle in early stages