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ChaC1, as a tumor-influencing factor, enhances ER stress, contributing to necroptosis and ferroptosis of multiple cancers, including metastatic melanoma (64), breast (54), prostate (65) and primary liver cancer (66), Burkitt's Lymphoma (67), head and neck squamous cell carcinoma (68), glioblastoma multiforme (GBM) (69), oral squamous cell carcinoma, T lymphoblastic leukemia Molt4 cells and colitis-associated carcinogenesis (15)