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Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request

Therapy for leaky gut syndrome should include dietary modification and supplementation with probiotics and prebiotics and, perhaps the aforementioned compounds

The protocols for peptide stacking apply similarly to oral formulations

Recent multi-omics analyses by Cappellani et al., for instance, have provided strong genetic and proteomic evidence linking DR pathogenesis directly to the activation of specific immune pathways, including the complement system and adaptive T-cell responses [53, 58, 59]