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New advances in in vivo applications of gated mesoporous silica as drug delivery nanocarriers
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Damit eine therapeutisch nutzbare Glutathion-Therapie in therapeutisch wirksamen und vertretbaren intrazellulren Konzentrationen ber unterschiedliche Applikationswege (oral-enteral, nasal, buccal, sublingual, per inhalationem, vaginal, rektal, intracutan, subcutan, intramuskulr, intravens, per infusionem, intraarteriell) mglich ist,mu das Molekl mit intakter SH-Gruppe intrazellulr zur Wirkung kommen knnen und gut membrangngig sein.So that therapeutically usable glutathione therapy in therapeutically effective and justifiable intracellular concentrations is possible via different application routes (oral-enteral, nasal, buccal, sublingual, by inhalation, vaginal, rectal, intracutaneous, subcutaneous, intramuscular, intravenous, by infusion, intra-arterial) , the molecule with an intact SH group must be able to take effect intracellularly and be well membrane-permeable
J.de GraafI
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