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Avoid taking high-dose B6 supplements without consulting your doctor: While the daily upper limit is set at 100 mg pyridoxine, there have been reported cases of pyridoxine-induced neuropathy in people taking 25 to 50 mg per day for longer than six months

This process, known as osteoarthritis, can lead to: persistent stiffness pain during walking reduced mobility swelling after activity difficulty climbing stairs progressive loss of joint function Although osteoarthritis is often associated with aging, previous injuries, excess body weight, genetics, and occupational demands can all contribute to its development

Brain and Behavior , 10 (8)