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FIGURE 3 3.4 Hesperetin and Naringenin triggered activation of TGR5 receptor Since Hesperetin and Naringenin activated the cAMP/PKA/[Ca 2+ ] i signaling pathway and promoted GLP-1 secretion in L cells, this activation effect closely resembled those resulting from G protein coupled receptor (GPCR) activation, so we speculated them to be GPCR agonists

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