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Long-term use of carbamazepine, phenytoin, and rifampin can significantly reduce the steady-state plasma concentrations of these drugs, leading to treatment failure

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In addition, forestomach tissues have the potential to convert HMB into Met, given the high enzymatic activities found in the rumen and omasum, which allows the conversion of D- and L-isomers of HMB into the L-Met precursor (Lobley et al., 2006b)

It promotes angiogenesis through VEGF pathway activation, modulates nitric oxide production, and produces cytoprotective effects in connective tissue, vascular endothelium, and gastrointestinal epithelium