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En pacientes con diabetes tipo 2, en comparacin con placebo, semaglutida logr las siguientes reducciones relativas de glucagn: glucagn en ayuno (8-21%), respuesta de glucagn postprandial (14- 15%) y concentracin media de glucagn a las 24 horas (12%)
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Clinical trials for semaglutide (including the STEP program for weight loss and SUSTAIN for diabetes) all used once-weekly dosing as the standard protocol
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Starting with a low dose, typically 3 mg, allows the body to adjust to the medication, reducing the likelihood of gastrointestinal side effects
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