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Acharya, J
People with obesity have been shown to be at an increased risk of other serious weight-related comorbidities such as certain types of cancer, heart disease, strokes, hypertension (high blood pressure), metabolic disorders, and an increased risk of developing diabetes
20 The recent ESC/EASD guidelines 21 accept the beneficial effect of metformin in primary prevention in newly diagnosed type 2 diabetes without cardiovascular disease (the UKPDS cohort), and the majority of patients in the recent CVOTs received metformin before or concurrently with the newer drugs under test
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