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The effect of prepregnancy body mass index on the risk of gestational diabetes mellitus: a systematic review and dose-response meta-analysis
While Glu9 of GLP-1 formed strong and persistent hydrogen bond and van der Waals interactions with R190 2.60 , Y152 1.47 , and to a lesser extent, Y148 1.43 , the polar side chain of Gln3 in oxyntomodulin only formed weak and very transient hydrogen bonds with these residues, and van der Waals interactions only with Y148 1.43 (Movie S1, Supplementary Table 3)
Together, these changes trigger a downward motion of the key toggle-switch activation residue W251 6.48 and its interaction with M121 3.40 , thereby assisting TM6 relocation (Fig
That gap is often the difference between fast progress and a plateau
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