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This variation is largely influenced by genetic differences in the enzymes responsible for its production and regeneration (1)
Vascular regenerative therapies should therefore restore both barrier structure and substrate exchange across the NVU
To assess the efficacy of combination treatment, tumour-bearing mice were treated as above with 5FU + metformin and CC3-quantified, showing an increase in average cell death per tumour per mouse with combination treatment (Extended Data Fig
Typically, an initial series of treatments may be recommended, ranging from once to twice a week over four to eight weeks
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