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Similarly, neratinib, a potent irreversible pan-tyrosine kinase inhibitor, has been shown to promote ferroptosis and to inhibit brain metastasis in a novel syngeneic model of spontaneous human epidermal growth factor receptor 2-positive breast cancer metastasis [122]
This dataset comprises 61% of B
Erastin, a ferroptosis inducer, binds to VDAC2 and VDAC3 on the outer mitochondrial membrane, inducing mitochondrial dysfunction and oxidant release, ultimately triggering ferroptosis in tumor cells
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