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By silencing NNMT, it enables a natural uptick in NAD levels, leading to enhanced mitochondrial function, lean mass preservation, and fat metabolism without overstimulation

Nrf2 knockout rats and their wild type counterpart were obtained by cross breeding heterozygous animals generously provided by Julian Lombard and Aron Geurts, Medical College Wisconsin, Milwaukee [22]

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The effect of inosine in adipocytes was shown to be exerted through the activation of PKA which in turn enhances fat metabolism via increased UCP-1 activity