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The BBB highly controls the neuronal microenvironment by supplying the brain with nutrients and protecting it from potentially harmful molecules [2]

PubMed Hsieh, M.J., Liu, H.T., Wang, C.N., Huang, H.Y., Lin, Y., Ko, Y.S., Wang, J.S., Chang, V.H., & Pang, J.H

The principle behind the leaky gut theory is that endogenous (e.g., psychological stress, intestinal inflammation) and exogenous factors (e.g., diet, alcohol intake) can increase intestinal permeability, allowing the entrance of food antigens, commensal or pathogenic bacteria and bacterial components into the lamina propria and later on into the systemic circulation, provoking the systemic inflammation described in different disease conditions

Polymorphisms in interferon regulatory factor 7 reduce interferon- responses of plasmacytoid dendritic cells to HIV-1