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This is the first large study the authors could find that puts the question to a systematic test, using health records from Penn Medicine, an academic system covering more than 6.5 million patients around Philadelphia, Delaware, and southern New Jersey

Math assumes the Phase 3 TRIUMPH titration above

In cohort 2, participants with body weight plateau maintained ~79% of weight loss with orforglipron compared to ~38% with placebo

It was approved by the Australian Therapeutic Goods Administration (TGA) in August 2024 for chronic weight management in adults with obesity or who are overweight with at least one weight-related health condition