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Anticoagulants EDTA [256, 468], sodium citrate [413], and heparin [469, 470] are acceptable

Hepatic IGF-1 is produced by the liver under GH stimulation and circulates throughout the body in the IGFBP-3/ALS ternary complex

Hormonal imbalances, such as those occurring during pregnancy, with birth control pills, or from hormone replacement therapy, can also contribute to overgrowth

Its findings the safe dose range, how the compound behaves in humans, early signs of biological activity feed directly into Phase 2, where the drug is studied in patients for the first time, and therefore for the first time therapeutic efficacy is tested and the most optimal dose is investigated