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Sci Rep 10 , 17078 (2020)

51-OR: A Phase 2, Randomized, Double-blind, Placebo-controlled, Dose-finding Study of BI 456906 in people with overweight/obesity

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Therapeutic Applications: Cellular Senescence: Age-related decline in cellular function and vitality DNA Damage Accumulation: Environmental and chronological genomic stress Mitochondrial Dysfunction: Impaired cellular energy production systems Metabolic Dysregulation: Altered cellular metabolism and repair processes Inflammatory Aging: Chronic low-grade inflammatory responses Oxidative Stress: Free radical damage and antioxidant system decline Cellular Optimization Mechanisms: NAD+ serves as a crucial cofactor in cellular energy metabolism, DNA repair processes, and gene expression regulation