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Molecules, 2011

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Hepatic impairment (OFV = 1.281), water volume 50 mL vs 120 mL (OFV = 3.328), age 65 years (OFV = 3.024), sex (OFV = 0.102) and renal impairment (OFV = 2.099) were excluded in the final model (in that order)

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Specific genetic variants in the GLP1R gene (such as rs6923761) and the GIPR gene affect receptor sensitivity and signaling efficiency, meaning some patients achieve better results and fewer side effects with dual-agonist tirzepatide, while others respond better to semaglutide's single-pathway approach

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