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The total synthesis of glucagon had been achieved in 1968 by a large research group headed by Erich Wnsch in Munich, Germany [26], using painstaking solution methodology to create and then stitch together smaller fragments to obtain the full molecule
But GLP-1 medications, particularly the newer dual and triple agonists, are closing that gap with each generation
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Avoid repeated cycles of freezing and thawing, as these can compromise peptide integrity
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