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Overuse of glutathione for skin lightening, particularly through unauthorized or non-sterile injections, can pose risks such as kidney stress or interference with natural melanin production

et al., Front Mol Biosci, 2022

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Cellular studies demonstrate increased lipolysis and fatty acid oxidation in differentiated adipocytes Animal models show reduced diet-induced obesity and improved insulin sensitivity with NNMT inhibition NAD+ metabolomics studies confirm restoration of cellular NAD+ and SAMe pools following NNMT blockade These findings are based on preclinical and clinical research