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Lastly, our study cohort was predominantly Caucasian and male, reflective of the population cared for within the VHA system, thus results may not be generalizable to a wider population, although some recent studies found that VHA population have similar health characteristics as individuals with other insurance coverage suggesting greater generalizability

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7 The mechanisms of IGF-1 for enhancing tendon regenerative healing Although the aforementioned studies demonstrate the therapeutic potential of IGF-1 in promoting tendon regenerative healing in vivo , the underlying mechanisms remain incompletely understood