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Dulaglutide is covalently linked to human immunoglobulin IgG 4 heavy chain molecules to reduce immunogenicity, enhance water solubility, and avoid degradation by DPP-4
Glucagon-like peptide 1 (GLP-1) can reverse AMP-activated protein kinase (AMPK) and S6 kinase (P70S6K) activities induced by fluctuations in glucose levels in hypothalamic areas involved in feeding behaviour
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