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Most clinically important overlap: Candida overgrowth is a primary cause of intestinal hyperpermeability (leaky gut), which in turn drives systemic inflammation, food intolerances, and autoimmune activation

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Senescent cells are known for their pro-inflammatory secretory phenotype, termed the Senescence-Associated Secretory Phenotype (SASP), which FOXO4-DRI effectively reduces, improving tissue function