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One surgical technique that you might have heard of is the Natural Orifice Intracorporeal Anastomosis (NICE) technique, in which the diseased portion of your colon is removed through the rectum, rather than through a separate incision in your abdomen

In a phase 2 clinical trial, retatrutide demonstrated significant improvements in glycemic control and substantial weight loss in participants with type 2 diabetes over a 36-week period

Once treatment ends, weight regain is common unless users adopt and maintain lifestyle changes like diet and exercise throughout and after medication use

Underlying endocrine disorders frequently diminish treatment response