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Why it matters: GLP-1 use surged in 2025 and will grow this year as the drugs expand beyond diabetes and weight loss into cardiovascular, kidney and liver disease, sleep apnea, and other indications in development
The latter study also identified lysosomes as a major post-endocytic GLP-1R destination, raising the possibility that prolonged agonist exposure might result in GLP-1R degradation
doi: 10.1136/bmjdrc-2021-002300 77
This is done because the vial is a vacuum, and you need to add an equal amount of air to regulate the pressure, making it easier to draw the medication into the syringe
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