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The repertoire of natural IgA is restricted and affinity maturation is limited, although the heavy-chain variable region genes used by IgA-producing plasma cells in the gut are somatically hyper-mutated, to diversify antibody specificity [42]

While studies have indicated a link between vitamin B12 and sleep regulation, the exact mechanism is not entirely understood

It stabilizes serotonin metabolism by inhibiting the enkephalinase enzyme, thus prolonging the action of endogenous enkephalins