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GLP-1 analogues delay gastric emptying ( When initiating GLP-1based therapy, clinicians should adhere to the principle of do no harm , particularly during the early phases of treatment when gastrointestinal adverse effects are most likely to emerge ( Potentially the easiest way to prevent nausea and vomiting is by starting at a low dose ( In most cases of Grade 1 or 2 nausea, maintaining the current dose for one to two additional dosing intervals is sufficient to allow symptom resolution
The economic and clinical burden of NASH in individuals with Type 2 Diabetes (T2D) underscores the need for effective treatments
Importantly, GLP-1 loses its inhibitory effect on glucagon secretion when blood glucose levels fall, allowing an appropriate glucagon response to hypoglycaemia
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