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5 This alone predicts that a hypothetical AOD-9604 trial enrolling predominantly East Asian participants would show lower mean fat-loss response than a European-ancestry cohort at the same dose, not because the drug works differently pharmacologically, but because a larger fraction of patients would carry the blunting allele
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Raghav Kathuria Address Plot No
High-dimensional approaches (multiplex cytokine panels, mass cytometry, and single-cell RNA sequencing) consistently reveal PD-associated peripheral immune signatures elevated IL-6, TNF-, IL-1, shifts toward Th1/Th17 polarization, and expansion of pro-inflammatory monocyte subsets which correlate with motor severity and progression in multiple cohorts
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