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Biomarkers for endothelial function, insulin sensitivity, intracellular signaling, maintaining DNA integrity , inflammation, metabolic flexibility, mitophagy (recycling old and damaged mitochondria) and cellular senescence (also called "zombie cells" as these cells have lost proper function, harm nearby cells and do not die off) are all favorably affected

Rotate sites with each injection to prevent injection site reactions and lipodystrophy

GLP-1 and GIP/GLP-1 medications significantly slow gastric emptying, which can affect the absorption of oral medications, including oral estrogen or progesterone formulations

The most commonly reported issues are gastrointestinal in nature