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However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships

As for clinical correlates, Vit B12 deficiency and HHcy do predict more rapid motor progression and cognitive dysfunction among PwPD and thus modulate PD clinical phenotypic variability

Energy levels dip, skin loses its radiance, and our immune system may struggle to cope with daily stressors

Investigation includes liver function tests, renal function, full blood count, and imaging if malignancy or liver disease suspected