Protect Your Metabolism While Losing Weight When you go on a diet, you dont just lose fat you lose muscle too Losing muscle is a problem because muscle burns more calories than fat, and even burns calories when you are at rest. Harvard Health explains that muscle mass is one of the strongest determinants of basal metabolic rate (BMR), meaning the more muscle mass you have, the higher your BMR will generally be. Separately, Cleveland Clinic notes that cutting calories too drastically, especially protein, can lead the body to break down muscle for fuel, and it emphasizes that muscle mass plays an important role in keeping your metabolism powered up. John Peel explains it clearly in his GLP-1 support strength series: The goal is not just watching the scale move

Emerging evidence indicates their potential role in the management of diverse obesity-related comorbidities, including metabolic dysfunction-associated steatotic liver disease, obstructive sleep apnea, polycystic ovary syndrome, neurodegenerative disorders, and even substance use disorders
Tretinoin IS retinoic acid already in active form, so its far more potent and works much faster
Theres really no long-term human data