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Cardiovascular benefits associated with some GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) observed in clinical trials are likely to diminish after discontinuation, though the exact persistence of these benefits remains uncertain
Patients with chronic heartburn, especially those on medications that affect gastrointestinal motility like semaglutide, should be monitored for signs of Barretts esophagus through regular endoscopic examinations
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Potential side effects leading to dose reductions before maximum effects seen
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