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Generally, there are no high concentrations of the drug in the tissues because the drug is susceptible to enzymatic degradation and is quickly excreted
They play key roles in brain cell structure and function
Poor Diet : Diets low in fruits, vegetables, and nutrient rich foods may limit the building blocks needed for glutathione production
45 Liver cytochrome P450 (CYP450) enzymes regulate the biotransformation of targeted agents (e.g., imatinib, erlotinib), and polymorphisms in these enzymes can result in therapeutic failure or toxicity
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