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If vitamin B 12 intake ceases, deficiency would usually not develop for at least 1-2 years, sometimes even longer
On top of that, checking B12 blood levels once a year is a very poor indicator of true B12 status
Clinical trials used doses as high as 1 mg per day without safety concerns, but 300 mcg is the most commonly referenced dose in peptide medicine literature and in the investigational protocols that have been published since the formal trials concluded
the product information notes that refrigeration can cause a color change (darker yellow) which does not affect safety or effectiveness
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