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JAMA 325(14):14141425
Damage to the endothelium is a hallmark of diabetic complications, and reduced glutathione levels correlate with worsening endothelial dysfunction
Retatrutide and similar medications reach these central receptors, where they modulate dopaminergic neurotransmission through several mechanisms
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According to the researchers, their findings broadly suggest that small-molecule GLP-1s could have applications in dysregulating reward signaling, creating implications for the drugs treatment of substance-use disorder and binge-eating
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