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This review focuses on the cardiovascular protection associated with use of GLP-1RAs, and outlines how the field may evolve in the near future with the introduction of dual or triple incretin receptor co-agonists

Excretion Pathways Elimination occurs through both renal and hepatic routes: Primary urinary excretion accounting for approximately 53% of administered dose for GLP1 Fecal elimination contributing approximately 19% of dose excretion Minimal intact peptide in urine (approximately 3.1% for GLP1

These signs go beyond normal pharmacological reactions and could indicate a complication

Others underdose for weeks and wonder why nothing is happening