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Scheduling and combination strategies that maintain pressure on ectopic cells while preserving antioxidant capacity in nonlesional compartments warrant systematic evaluation, supported by pharmacokineticpharmacodynamic mapping and biomarker programs that verify on-lesion lipid peroxidation and redox modulation while monitoring marrow, hepatic, renal, and mitochondrial safety
Patient selection should be biomarker-guided, emphasizing lesions with molecular features consistent with ferroptosis susceptibility and delivery feasibility (102)
Spasmolytic and uroprotective effects of apigenin by downregulation of TGF- and iNOS pathways and upregulation of antioxidant mechanisms: in vitro and in silico analysis
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