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Nocturnal hypoglycemia can cause nighttime awakenings, sweating, and restlessness, so patients on combination therapy should monitor bedtime glucose levels if sleep disruption occurs

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Moreover, dapagliflozin markedly alleviates neuronal oxidative stress, tau phosphorylation and amyloid- production due to the ability to counteract neuronal apoptosis and upregulating glial cell-derived neurotrophic factor ( Alzheimers disease is also characterized by a reduced level of neuronal acetylcholine and the first line pharmacological treatment is based on the use of acetylcholinesterase inhibitors (Shaikh et al., 2016)