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Narrow therapeutic window drugs across the board need more frequent level checks
sarcopenia risk in older adults Refeeding syndrome risk in patients who are already nutritionally compromised Psychiatric Signals: What We Know and Do Not Know The largest psychiatric safety meta-analysis to date 80 randomized controlled trials, over 107,000 patients found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall, including suicidal ideation (Pierret et al., JAMA Psychiatry, 2025)
Semaglutide treatment starts at 0.25 mg weekly and gradually increases over 16-20 weeks to a maintenance dose of 2.4 mg
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