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On the other hand, the SURPASS-5 study showed tirzepatide at doses up to 15 mg weekly reduced HbA1c by up to 2.34% and produced weight loss of up to 10.5 kg over 40 weeks, outperforming placebo by a wide margin (NCBI Bookshelf)

Preventive effects of procyanidin A2 on glucose homeostasis, pancreatic and duodenal homebox 1, and glucose transporter 2 gene expression disturbance induced by bisphenol A in male mice