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Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala(2)GIP in rat model of Huntingtons disease
Historically, FDA-approved CD3-based TCEs have been monovalent to the disease target until recently, with agents like Glofitamab (CD20-CD3 TCE with two CD20-binding Fabs) and thus have been largely limited to uniquely expressed antigens such as CD19
While these results were statistically significant, they represent modest weight loss, particularly when compared to appetite-suppressing medications that typically produce more dramatic short-term results
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