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Deficiencies in B12 or defects in methionine synthase will result in 5-methyl-THF trapping with the result being the development of megaloblastic anemia due to the block in nucleotide production and the inability of bone marrow erythroblasts to proceed through S-phase of the cell cycle
They also tend to be less nutrient dense, which matters more when overall food intake is lower
Available from: Region Stockholm (2023) VAL databaserna: Datalager fr uppfljning av vrdhndelser i Region Stockholm
These are the effects of L-Carnitine that have been studied and confirmed and may be in use medically
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