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The glucagon receptor component is hypothesised to increase energy expenditure and promote fat breakdown (lipolysis), potentially contributing to the substantial weight loss observed in early-phase trials
Abdominal Fat Weight Loss with Semaglutide Abdominal Fat Weight Loss with Semaglutide Clinical studies have shown that use of semaglutide improves body composition by reducing excess body fat, including abdominal fat, and increasing the proportion of lean body mass
This pathway has expanded substantially in 2024-2025 and offers coverage even in plans that exclude obesity drugs
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