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The pathophysiology of ICH involves both primary mechanical damage from hematoma expansion and secondary biochemical and biomechanical alterations that exacerbate neuronal injury (181)

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CCR8 also has a unique PMS activation motif instead of the canonical P 5.50 I 3.40 F 6.44 sequence, and is the only chemokine receptor that has a Ser instead of an aromatic residue at position 6.44 (Supplementary Fig