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This seronegativity could reflect a lack of exposure to the virus or could indicate early control of the virus upon exposure and abortive infections [67]
A common research framing is a defined block (often 812 weeks) followed by an off period, rather than indefinite continuous use a conservative default given the absence of long-term human data
To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed
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