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The isolated TIF was snap-frozen in liquid nitrogen and stored at 80 C before analysis

Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

Brand-name pricing Tirzepatide: The list price for Mounjaro (diabetes indication) or Zepbound (weight management indication) is approximately $1,080 per month for a 4-week supply

PT-141 Bremelanotide is a modified derivative of alpha-melanocyte stimulating hormone (a-MSH)